What Is VDR?

VDR is a gene that encodes a vitamin-D receptor protein. This protein regulates calcium absorption and bone development. A variant of the gene, rs2228570 (FokI polymorphism) is associated with reduced bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the temporal and reciprocal pattern of off- and on- occupancy of the VDRE by two components, and is influenced by chromosomal location and binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes have VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository for information and documents pertinent to legal transactions, business or proceedings that are restricted in viewing printing, downloading, or viewing. It utilizes a central server as well as an extranet connection which is an Internet connection that has restricted access, which allows controlled login time periods during which users are able to view the data and documents.

VDRs are used most often by investment banks and businesses involved in mergers and acquisitions. They require an encrypted platform to share information with investors or buyers in a clear and transparent manner, and due diligence may require large quantities of data. Life science companies also utilize VDRs to keep everything from clinical trial results to HIPAA documentation.

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